Author's response to reviews Title:Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) Study Authors:
نویسندگان
چکیده
Line 54: How is the variant associated with mean telomere length? Is it associated with increased/decreased length? The A allele of rs2736100 was associated with decreased telomere length. This is described in the last paragraph of the Background section. Methods Line 144: Should read “Six SNPs” rather than “Six (6) SNPs”. This error has been corrected. State whether the assumptions of the cox proportional hazards models were met. The proportional hazards assumption was met for all of the TERT SNPs tested individually by race with the exception of rs2736122 (model 1) and rs4246742 (models 1 and 2) when analyzed in whites for association with incident CHD, and rs2853668 (model 1) in the analyses of mortality in whites. This has been added to the statistical analysis section. Specify in manuscript text, report the variables adjusted for in the cox proportional hazards models. The variables adjusted for in the two Cox proportional hazards models have been added to the statistical analysis section. Model 2 now includes the same covariates for the analyses of incident coronary heart disease, incident stroke, and mortality. As a result, some of the data displayed in Tables 5 and 6 has been slightly changed without any impact on the conclusions made in the manuscript. Specify in manuscript text, the statistical tests used to generate p-values in the provided tables. The statistical tests used to generate the p-values have been added to the table legends (Tables 1, 3, 4, 5, and 6). Comparison of continuous variables between groups by t-tests and categorical variables by chi-squared tests has been added to the statistical analysis section.
منابع مشابه
Author's response to reviews Title:Birth weight and the risk of atrial fibrillation in whites and African Americans: the Atherosclerosis Risk in Communities (ARIC) Study Authors:
متن کامل
Rat adipose-derived mesenchymal stem cells aging reduction by zinc sulfate under extremely low frequency electromagnetic field exposure is associated with increased telomerase reverse transcriptase gene expression
Zinc as an essential trace element was reported to be involved in regulation of the growth and aging of cells. In this study, rat adipose-derived mesenchymal stem cells were exposed to extremely low frequency electromagnetic field (ELF-EMF) of 50 Hz and 20 mT to evaluate whether exposure to ELF-EMF in the presence of zinc sulfate (ZnSO4) affects the telomerase reverse transcriptase (...
متن کاملAtorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism.
UNLABELLED Statins are one of the most potent drugs in delaying age-related inflammatory changes in the arterial vessel wall, slowing down the progression of atherosclerosis. Statins have also been shown to abrogate telomere-attributed cardiovascular risk. The goal of our study was to explore a potential effect of atorvastatin on telomerase activity in peripheral blood mononuclear cells (PBMCs)...
متن کاملTelomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages.
OBJECTIVE Telomerase serves as a critical regulator of tissue renewal. Although telomerase activity is inducible in response to various environmental cues, it remains unknown whether telomerase is activated during the inflammatory remodeling underlying atherosclerosis formation. To address this question, we investigated in the present study the regulation of telomerase in macrophages and during...
متن کاملEffect of Resistance Exercise and Vitamin C Intake on Expression of Telomerase Reverse Transcriptase and Telomere Repeat Binding Factor-2 Genes and the Diameter and Number of Myofibrils in Old Rats
Introduction: Cell aging is one of the most important and fundamental step in cellular behavior and reduces muscle mass and myofibrils. This study aims to investigate the effect of resistance exercise along with vitamin C consumption on the expression of Telomerase Reverse Transcriptase (TERT) and Telomere Repeat Binding Factor-2 (TRF2) genes and the diameter and number of skeletal muscle myofi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015